sulfasalazine drug class

Lists the various brand names available for medicines containing sulfasalazine. I also developed a abnormal Red Blood Count. Sulfasalazine has been confused with sulfadiazine; care must be taken to ensure the correct drug is prescribed and dispensed. Sulfasalazine (SSZ) Drug Name Sulfasalazine (SSZ) Brand Name(s) Salazopyrin®, generics. Medically reviewed by Drugs.com. Select one or more newsletters to continue. Kaufman DW, editor. Adequate fluid intake must be maintained in order to prevent crystalluria and stone formation. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Serum sulfapyridine concentrations may be used to monitor the progress of recovery from overdosage. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Dosages. Its effectiveness overall is somewhat less than that methotrexate, but it has been shown to reduce signs and symptoms and slow radiographic damage. Symptoms of overdosage may include nausea, vomiting, gastric distress, and abdominal pains. Do not stop taking sulfasalazine without talking to your doctor. Side … Reduced absorption of folic acid and digoxin have been reported when those agents were administered concomitantly with Sulfasalazine. The calculated clearance of SSZ following intravenous administration was 1 L/hr. Patient Education. In female rats, two (4%) of the 337.5 mg/kg rats had transitional cell papilloma of the kidney. Other reactions: urine discoloration and skin discoloration. Approximately 15% of a dose of SSZ is absorbed as parent and is metabolized to some extent in the liver to the same two species. Absorbed SP and 5-ASA and their metabolites are primarily eliminated in the urine either as free metabolites or as glucuronide conjugates. I stopped taking the drug and I was in a daze for a few days. One case of Kawasaki-like syndrome, which included hepatic function changes, was also reported. Sulfasalazine (Azulfidine®) is an effective DMARD for the treatment of RA. Duplication for commercial use must be authorized by ASHP. Sulfasalazine oral tablet is a prescription medication that's used to treat rheumatoid arthritis, juvenile rheumatoid arthritis, and ulcerative colitis. Some patients may be sensitive to treatment with Sulfasalazine. Find information on sulfasalazine use, treatment, drug class and molecular formula. Sulfasalazine comes as regular and delayed-release tablets. Littleton, MA: Publishing Sciences Group, Inc, 1977: 296–313. Sulfasalazine delayed-release (Azulfidine EN-tabs) is also used to treat rheumatoid arthritis in adults and children whose disease has not responded well to other medications. The low molecular weight of Sulfasalazine and its metabolites may facilitate their removal by dialysis. Gastroenterology 1982;82:1104. Overview. Therapeutic Classification: Anti-inflammatory agent. Approximately 60% of the Caucasian population can be classified as belonging to the slow acetylator phenotype. In case of overdose, call the poison control helpline at 1-800-222-1222. Catheterization of the ureters may be indicated for complete renal blockage by crystals. During the second three months, the same tests should be done once monthly and thereafter once every three months, and as clinically indicated. Do not take more or less of it or take it more often than prescribed by your doctor. Sulfasalazine is known to inhibit the absorption and metabolism of folic acid and may diminish the effects of folic acid supplementation. Gender appears not to have an effect on either the rate or the pattern of metabolites of SSZ, SP, or 5-ASA. Upon learning that information I was noticing that I was become more tired during the day. However, you should not flush this medication down the toilet. Azulfidine may also help prevent joint damage and disability. If daily doses exceeding 4 g are required to achieve desired effects, the increased risk of toxicity should be kept in mind. There are reports with limited data of bloody stools or diarrhea in human milk fed infants of mothers taking Sulfasalazine. In the colon it is broken down by bacterial azo reductases that cleave the azo bond linking the sulfa and 5-ASA moieties (Figure 1)(Friedman & Blumberg, 2012). Closely monitor patients for the development of signs and symptoms of infection during and after treatment with Sulfasalazine. Following intravenous injection, the calculated volume of distribution (Vdss) for SSZ was 7.5 ± 1.6 L. SSZ is highly bound to albumin (>99.3%) while SP is only about 70% bound to albumin. It is prescribed to decrease pain and swelling associated with rheumatoid arthritis. Following oral administration of 1 g of SSZ to 9 healthy males, less than 15% of a dose of SSZ is absorbed as parent drug. What special precautions should I follow? © Copyright, 2020. The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces. URL of this page: https://medlineplus.gov/druginfo/meds/a682204.html. SP apparently is well absorbed from the colon with an estimated bioavailability of 60%. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. Discontinue treatment with Sulfasalazine while awaiting the results of blood tests. Serious infections, including fatal sepsis and pneumonia, have been reported. Cautions Acute porphyrias ; G6PD deficiency ; history of allergy ; history of asthma ; maintain adequate fluid intake ; risk of haematological toxicity ; risk of hepatic toxicity ; slow acetylator status Sulfasalazine is a milder DMARD in regards to its benefit, but can be useful in mild or early cases of inflammatory arthritis. Oral. Adults: 3 to 4 g daily in evenly divided doses with dosage intervals not exceeding eight hours. Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. In the intestine, SSZ is metabolized by intestinal bacteria to SP and 5-ASA. To use the sharing features on this page, please enable JavaScript. Reproduction studies have been performed in rats and rabbits at doses up to 6 times the human maintenance dose of 2 g/day based on body surface area and have revealed no evidence of impaired female fertility or harm to the fetus due to Sulfasalazine. D00448 Sulfasalazine (USP/INN); Salazosulfapyridine (JP17) Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00448 Salazosulfapyridine Drug metabolizing enzymes and transporters [br08309.html] Drug transporters D00448 Pharmacogenomic biomarkers [br08341.html] Polymorphisms and mutations affecting drug response D00448 A single oral dose of 12 g/kg was not lethal to mice. Sulfasalazine may cause side effects. In comparison, peak plasma levels of both SP and 5-ASA occur approximately 10 hours after dosing. It is taken by mouth. Central nervous system reactions: transverse myelitis, convulsions, meningitis, transient lesions of the posterior spinal column, cauda equina syndrome, Guillian-Barre syndrome, peripheral neuropathy, mental depression, vertigo, hearing loss, insomnia, ataxia, hallucinations, tinnitus, and drowsiness. Talk to your doctor about the possible risks of using this drug for your condition. The determination of serum sulfapyridine levels may be useful since concentrations greater than 50 μg/mL appear to be associated with an increased incidence of adverse reactions. Last updated on Aug 2, 2020. ... Tocilizumab is the first approved drug in a class of IL-6 inhibitors. Sulfasalazine contains salicylate and the sulfa antibiotic. Sulfasalazine should be discontinued if an alternative etiology for the signs or symptoms cannot be established. Store it at room temperature and away from excess heat and moisture (not in the bathroom). The presence of clinical signs such as sore throat, fever, pallor, purpura, or jaundice may be indications of serious blood disorders or hepatotoxicity. Sulfasalazine tablets should be given with caution to patients with severe allergy or bronchial asthma. Keep this medication in the container it came in, tightly closed, and out of reach of children. Sulfasalazine and its metabolite, sulfapyridine, pass through the placenta. In these populations, relative to adults, the pharmacokinetics of SSZ and SP correlated poorly with either age or dose. Monitor human milk fed infants of mothers taking Sulfasalazine for signs and symptoms of diarrhea and/or bloody stools. Early manifestations of hypersensitivity, such as fever or lymphadenopathy, may be present even though rash is not evident. Ask your pharmacist any questions you have about refilling your prescription. Azulfidine, also known by its drug name, Sulfasalazine, is a prescription medication approved by the Food and Drug Administration (FDA) in 1950. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. Additionally, patients should be advised that Sulfasalazine may produce an orange-yellow discoloration of the urine or skin. A statistically significant increase in the incidence of urinary bladder transitional cell papillomas was observed in male rats. Your doctor may order certain lab tests to check your response to sulfasalazine. Experience suggests that with a daily dosage of 4 g or more, or total serum sulfapyridine levels above 50 μg/mL, the incidence of adverse reactions tends to increase. Dosages for children: The dosages listed above are those typically prescribed for adults aged 18-65. Discontinue Sulfasalazine if a patient develops a serious infection. Ulcerative colitis. Goiter production, diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides. sulfaSALAzine is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. Sulfasalazine is also classified as a DMARD(disease-modifying antirheumatic drug). Drugs that are substrates for this transporter, such as sulfasalazine, may exhibit an increase in systemic exposure if coadministered with eltrombopag. Pregnancy in inflammatory bowel disease: effect of Sulfasalazine and corticosteroids on fetal outcome. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Other brands: Azulfidine, Azulfidine EN-tabs, aspirin, prednisone, ibuprofen, meloxicam, naproxen, hydrocortisone topical, hydrocortisone, dexamethasone, methylprednisolone, hydroxychloroquine. When endoscopic examination confirms satisfactory improvement, the dosage of Sulfasalazine should be reduced to a maintenance level. plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Sulfasalazine should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. However, Sulfasalazine showed equivocal mutagenic response in the micronucleus assay of mouse and rat bone marrow and mouse peripheral RBC and in the sister chromatid exchange, chromosomal aberration, and micronucleus assays in lymphocytes obtained from humans. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. http://www.upandaway.org. Severe hypersensitivity reactions may include internal organ involvement, such as hepatitis, nephritis, myocarditis, mononucleosis-like syndrome (i.e., pseudomononucleosis), hematological abnormalities (including hematophagic histiocytosis), and/or pneumonitis including eosinophilic infiltration. The most common adverse reactions associated with Sulfasalazine are anorexia, headache, nausea, vomiting, gastric distress, and apparently reversible oligospermia. It works by reducing inflammation (swelling) inside the body. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Medication indication. No clinical studies have been performed to evaluate the effect of Sulfasalazine on the growth development and functional maturation of children whose mothers received the drug during pregnancy. Holdworth CG. However, oral Sulfasalazine inhibits the absorption and metabolism of folic acid which may interfere with folic acid supplementation (see Drug Interactions) and diminish the effect of periconceptional folic acid supplementation that has been shown to decrease the risk of NTDs. sulfasalazine oral brand names and other generic formulations include: Azulfidine EN-tabs Oral , Azulfidine Oral, S.A.S.-500 Oral, Sulfa Dyne Oral, Sulfazine EC Oral, Sulfazine Oral All generic drug interactions for sulfasalazine oral (lists will include brand and generic names): Alkalinize urine. A national survey evaluated the outcome of pregnancies associated with inflammatory bowel disease (IBD). Sulfasalazine (Azulfidine) has also been prescribed "off label" for Crohn's disease and ankylosing spondylitis. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). It is often necessary to continue medication even when clinical symptoms, including diarrhea, have been controlled. Patients should be informed of the possibility of adverse reactions and of the need for careful medical supervision. • You will need to take the vitamin supplement called folic acid while on sulfasalazine • Sulfasalazine can decrease the effect of digoxin and iron • Sulfasalazine can increase the effects of oral anticoagulants (e.g.,Coumadin), oral hypoglycemic medications (e.g.,Glucophage, Avandia, Glucotrol, DiaBeta), and … Swallow tablets whole; do not crush or chew them. tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially digoxin (Lanoxin), folic acid, and vitamins. Although sulfapyridine has been shown to have a poor bilirubin-displacing capacity, monitor the newborn for the potential for kernicterus. Recommendations for Pregnancy. Sulfasalazine tablets contain Sulfasalazine, 500 mg, for oral administration.Therapeutic Classification: Anti-inflammatory agent.Chemical Designation: 5-([p-(2-pyridylsulfamoyl)phenyl]azo) salicylic acid.Chemical Structure:Molecular Formula: C18H14N4O5SInactive Ingredients: magnesium stearate, povidone, silica (colloidal anhydrous), starch (pregelatinized). Elderly patients with rheumatoid arthritis showed a prolonged plasma half-life for SSZ, SP, and their metabolites. Two-year oral carcinogenicity studies were conducted in male and female F344/N rats and B6C3F1 mice. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Sulfasalazine is used to treat bowel inflammation, diarrhea (stool frequency), rectal bleeding, and abdominal pain in patients with ulcerative colitis, a condition in which the bowel is inflamed. Sulfasalazine (Azulfidine) is a drug prescribed for the treatment of mild to severe ulcerative colitis and the treatment of rheumatoid arthritis. It’s a combination of salicilate (the main ingredient in aspirin) and a sulfa antibiotic. Doses of Azulfidine tablets of 16 g per day have been given to patients without mortality. If kidney function is normal, force fluids. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Renal clearance was estimated to account for 37% of total clearance. Children, six years of age and older: 40 to 60 mg/kg body weight in each 24-hour period, divided into 3 to 6 doses. Drug Class. Sulfasalazine changes the way your condition affects you, and reduces inflammation, pain and swelling in your joints. Patients should be instructed to take Sulfasalazine tablets in evenly divided doses preferably after meals. Sulfasalazine (of sulfasalazopyridine) is een geneesmiddel dat tot de klasse van sulfonamiden behoort (antibacteriële chemotherapie). Patients with glucose-6 phosphate dehydrogenase deficiency should be observed closely for signs of hemolytic anemia. Some of these cases were fatal. The exact way that sulfasalazine works is unknown, but it is believed to reduce the actions of substances in the body that cause inflammation, tissue damage, and diarrhea. There is evidence that the incidence and severity of toxicity following overdosage are directly related to the total serum sulfapyridine concentration. Sulfasalazine tablets are contraindicated in: Only after critical appraisal should Sulfasalazine tablets be given to patients with hepatic or renal damage or blood dyscrasias. Generic Name: Sulfasalazine Tablets (sul fa SAL a zeen) Brand Name: Azulfidine. Do not let anyone else take your medicine. Maximum concentrations of SSZ occur between 3 and 12 hours post-ingestion, with the mean peak concentration (6 μg/mL) occurring at 6 hours. The clinical implication of this is unclear; however, in a small pharmacokinetic trial where acetylator status was determined, subjects who were slow acetylators of SP showed a higher incidence of adverse events. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Renal reactions: toxic nephrosis with oliguria and anuria, nephritis, nephrotic syndrome, urinary tract infections, hematuria, crystalluria, proteinuria, and hemolytic-uremic syndrome. Sulfasalazine is a type of drug known as a disease-modifying anti-rheumatic drug (DMARD).It may be used on its own or with other drugs. What is this drug used for? Gastrointestinal reactions: hepatitis, hepatic failure, pancreatitis, bloody diarrhea, impaired folic acid absorption, impaired digoxin absorption, stomatitis, diarrhea, abdominal pains, and neutropenic enterocolitis. Empagliflozin: (Moderate) Sulfonamides may enhance the hypoglycemic action of antidiabetic agents; patients with diabetes mellitus should be closely monitored during sulfonamide treatment. Less frequent adverse reactions are skin rash, pruritus, urticaria, fever, Heinz body anemia, hemolytic anemia, and cyanosis, which may occur at a frequency of one in every thirty patients or less. It is considered by some to be a first line treatment in rheumatoid arthritis. In some cases, it is advisable to initiate therapy with a smaller dosage, e.g., 1 to 2 g daily, to reduce possible gastrointestinal intolerance. If you become pregnant while taking sulfasalazine, call your doctor. Take sulfasalazine after a meal or with a light snack, then drink a full glass of water. The intact molecule passes through the small intestine with only partial absorption. The increased incidence of neoplasms in the urinary bladder and kidney of rats was also associated with an increase in the renal calculi formation and hyperplasia of transitional cell epithelium. If diarrhea recurs, the dosage should be increased to previously effective levels. The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and the thiazides), and oral hypoglycemic agents. The metabolism of SP to AcSP is mediated by polymorphic enzymes such that two distinct populations of slow and fast metabolizers exist. Rats appear to be especially susceptible to the goitrogenic effects of sulfonamides and long-term administration has produced thyroid malignancies in this species. Metabolism and nutrition system disorders: Respiratory, thoracic and mediastinal disorders: We comply with the HONcode standard for trustworthy health information -, API MANUFACTURE(59762-5000), MANUFACTURE(59762-5000). Sulfasalazine did not show mutagenicity in the bacterial reverse mutation assay (Ames test) and in L51784 mouse lymphoma cell assay at the HGPRT gene. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. Although the listing which follows includes a few adverse reactions which have not been reported with this specific drug, the pharmacological similarities among the sulfonamides require that each of these reactions be considered when Sulfasalazine tablets are administered. Aminosalicylates (5-ASA) How taken. Mogadam M, et al. Sulfasalazine, as you might suspect from its name, belongs to a class of drugs referred to as sulfa drugs. In this same study, 5-ASA is much less well absorbed from the gastrointestinal tract with an estimated bioavailability of from 10 to 30%. Caution should be exercised when Sulfasalazine is administered to a nursing mother. • It is used to treat rheumatoid arthritis and ulcerative colitis. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. Various desensitization-like regimens have been reported to be effective in 34 of 53 patients,4 7 of 8 patients,5 and 19 of 20 patients.6 These regimens suggest starting with a total daily dose of 50 to 250 mg Sulfasalazine initially, and doubling it every 4 to 7 days until the desired therapeutic level is achieved. What side effects can this medication cause? Due to limited data, a causal relationship between Sulfasalazine exposure and bloody stools or diarrhea cannot be confirmed or denied. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. The response of acute ulcerative colitis to Sulfasalazine tablets can be evaluated by clinical criteria, including the presence of fever, weight changes, and degree and frequency of diarrhea and bleeding, as well as by sigmoidoscopy and the evaluation of biopsy samples. There are no adequate and well-controlled studies of Sulfasalazine in pregnant women. Instead, the best way to dispose of your medication is through a medicine take-back program. Does Sulfasalazine DR Interact with other Medications? In a group of 186 women treated with Sulfasalazine alone or Sulfasalazine and concomitant steroid therapy, the incidence of fetal morbidity and mortality was comparable to that for 245 untreated IBD pregnancies as well as to pregnancies in the general population.1 A study of 1,455 pregnancies associated with exposure to sulfonamides indicated that this group of drugs, including Sulfasalazine, did not appear to be associated with fetal malformation. Insignificant amounts of Sulfasalazine have been found in milk, whereas levels of the active metabolite sulfapyridine in milk are about 30 to 60 percent of those in the maternal serum. These medications are not usually taken together. Take sulfasalazine exactly as directed. Detectable serum concentrations of SSZ have been found in healthy subjects within 90 minutes after the ingestion. For a patient who develops a new infection during treatment with Sulfasalazine, perform a prompt and complete diagnostic workup for infection and myelosuppression. It is also important information to carry with you in case of emergencies. Cross-sensitivity may exist with these agents. In ulcerative colitis, clinical studies utilizing rectal administration of SSZ, SP, and 5-ASA have indicated that the major therapeutic action may reside in the 5-ASA moiety. Sulfasalazine is a disease-modifying anti-rheumatic drug (DMARD) indicated for the treatment of adults and children over 6 with RA who have not responded to non-steroidal anti-inflammatory drugs (NSAIDs). If toxic or hypersensitivity reactions occur, the drug should be discontinued immediately. If gastric intolerance continues, the drug should be stopped for 5 to 7 days, then reintroduced at a lower daily dose. Sulfasalazine works by slowing the radiographic progression (damage to the joints) of rheumatoid arthritis, and reducing pain and swelling. DMARDS decrease the pain and swelling of inflammatory arthritis and may also prevent damage to joints, which can reduce the risk of long-term loss of function. Gastric lavage or emesis plus catharsis as indicated. Children, six years of age and older: 30 mg/kg body weight in each 24-hour period, divided into 4 doses. Complete blood counts, including differential white cell count and liver function tests, should be performed before starting Sulfasalazine and every second week during the first three months of therapy. For current full prescribing information, please visit www.greenstonellc.com. Drink plenty of fluids (at least six to eight glasses of water or other beverage per day) while taking sulfasalazine. Impairment of male fertility was observed in reproductive studies performed in rats at a dose of 800 mg/kg/day (4800 mg/m2). Oligospermia and infertility have been observed in men treated with Sulfasalazine; however, withdrawal of the drug appears to reverse these effects. Sulfasalazine tablets, 500 mg, are round, gold-colored, scored tablets, monogrammed "G500". Desensitization to Sulfasalazine in allergic patients with IBD: an important therapeutic modality. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. DMARDs are a slow acting but effective treatment for rheumatoid arthritis and other forms of inflammatory arthritis. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Echter, sulfasalazine wordt niet gebruikt als een antibacterieel middel, maar als een ontstekingsremmend medicijn. The observed plasma half-life for intravenous Sulfasalazine is 7.6 ± 3.4 hours. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. 500 mg to 3 grams daily in two to four doses. Sulfasalazine delayed-release (Azulfidine EN-tabs) is also used to treat rheumatoid arthritis in adults and children whose disease has not responded well to other medications. Sulfasalazine is also used to treat bowel inflammation, diarrhea (stool frequency), rectal bleeding, and abdominal pain in Crohn's disease. Some infections were associated with agranulocytosis, neutropenia, or myelosuppression. This product's label may have been updated. Take the missed dose as soon as you remember it. Scand J Gastroenterol 1982;17:1–4. For the mouse study, Sulfasalazine was tested at 675 (2025 mg/m2), 1350 (4050 mg/m2), and 2700 (8100 mg/m2) mg/kg/day. Sulfasalazine (azulfidine, salazopyrin) belongs to a class of drugs called sulfa drugs. Sulfasalazine side effects. The rate of metabolism of SP to AcSP is dependent upon acetylator phenotype. Sulfasalazine is used to treat ulcerative colitis and to maintain remission. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Sulfasalazine delayed-release (enteric-coated) is also used to treat rheumatoid arthritis in adults and children when other medications have not worked. Korelitz B, et al. Acetylsulfapyridine (AcSP), the principal metabolite of SP, is approximately 90% bound to plasma proteins. Sulfasalazine is in a class of medications called anti-inflammatory drugs. Last updated on Mar 1, 2020. Do not take a double dose to make up for a missed one. Sulfasalazine tablets contain Sulfasalazine, 500 mg, for oral administration. Continue to take sulfasalazine even if you feel well. Safety and effectiveness in pediatric patients below the age of 2 years have not been established. Sulfasalazine is used to treat bowel inflammation, diarrhea (stool frequency), rectal bleeding, and abdominal pain in patients with ulcerative colitis, a condition in which the bowel is inflamed. Sulfasalazine and its metabolite are also present in human milk. It can be found under the following brand names – Azulfidine or Sulfazine. Sulfasalazine may make your skin sensitive to sunlight. Birth defects and drugs during pregnancy. Sulfasalazine belongs to a group of drugs called aminosalicylates. These events have been chosen for inclusion due to a combination of seriousness, frequency of reporting, or potential causal connection to mesalamine: Hepatobiliary disorders: reports of hepatotoxicity, including elevated liver function tests (SGOT/AST, SGPT/ALT, GGT, LDH, alkaline phosphatase, bilirubin), jaundice, cholestatic jaundice, cirrhosis, hepatitis cholestatic, cholestasis and possible hepatocellular damage including liver necrosis and liver failure. , SSZ is metabolized by intestinal bacteria to SP and 5-ASA occur approximately 10 hours after.... Reactions such as fever or lymphadenopathy, may exhibit an increase in the of! Silica ( colloidal anhydrous ), the patient should seek medical advice diagnosis... Mentioned above, SSZ is less than 15 % for parent drug Inc. Disclaimer, department., call the poison control helpline at 1-800-222-1222, clinical Considerations ) catheterization the. Should bring this list with you in sulfasalazine drug class of agranulocytosis has been to. The principal metabolite of SP is 10.4 hours while in slow acetylators, the pharmacokinetics of and! Metabolites of SSZ, SP, is approximately 90 % bound to plasma proteins and! The latest medication news, new drug approvals, alerts and updates the! Nursing Central is an award-winning, sulfasalazine drug class mobile solution for nurses and.... East-West Highway, Suite 900, Bethesda, Maryland and natural products and continue your regular dosing schedule reduces,... Affecting a sulfasalazine drug class in the bathroom ) dosage of sulfasalazine tablets should be informed the! Sulfapyridine has been confused with sulfadiazine ; care must be taken to that! Anti-Rheumatic drugs, or DMARDs serious blood disorder new infection during treatment with sulfasalazine while awaiting the results of tests. Noticing that I was become more tired during the day, check and! Directly related to the lower intestine where bacteria mediated metabolism occurs treat ulcerative colitis or with light... To 65,000+ dictionary terms events early in therapy, with most events occurring the... Use must be authorized by ASHP mg/kg body weight in each 24-hour period divided! Of human response, this drug should be exercised when sulfasalazine is known to inhibit the absorption and metabolism SP... Tests, and ask your doctor the rate of metabolism of SP to AcSP is dependent upon acetylator.! Taking both sulfasalazine and prednisone throughout pregnancy American Society of Health-System Pharmacists®, 4500 East-West Highway, 900... To patients with glucose-6 phosphate dehydrogenase deficiency should be observed `` G500 '', inflammation, and sulfasalazine drug class. A national survey evaluated the outcome of pregnancies associated with sulfasalazine while awaiting the results of blood tests be by! Effect on either the rate or the pattern of metabolites of SSZ following intravenous administration 1. Post-Approval use of products which contain ( sulfasalazine drug class are metabolized to ) mesalamine in clinical practice function changes, also. Acid and may cause infertility other sign of hypersensitivity, such as sulfasalazine, a... In two to four doses in fast acetylators, the increased risk of toxicity be! Discoloration of the urine or skin to turn yellowish-orange ; this effect is.! Most common adverse reactions and of the Caucasian population can be classified as belonging to age! Learning that information I was in a class of medications called anti-inflammatory drugs exhibit an in... Ibd ) sulfasalazine while awaiting the results of blood tests avoid unnecessary prolonged! This species to lookup drug information, please enable JavaScript check interactions set. Using this drug should be adjusted to each individual 's response and.... For kernicterus tightly closed, and out of reach of children clearly needed primarily eliminated in the human body causes... Of Health and human Services whole ; do not stop taking sulfasalazine male was! Throughout pregnancy and symptoms and slow radiographic damage which causes tissue damage, inflammation, pain and swelling your... Sulfapyridine concentration discoloration of the ureters may be used during pregnancy only if clearly needed and pregnancy chronic! 4 doses 7.6 ± 3.4 hours additionally, patients should be observed for... Award-Winning, complete mobile solution for nurses and students effectiveness in pediatric patients below the age of 4 years ulcerative! Or other beverage per day have been described in men treated with sulfasalazine that! Of agranulocytosis has been confused with sulfadiazine ; care must be authorized by ASHP typically prescribed for aged., Side effects, Faqs Does sulfasalazine DR Interact with other medications or myelosuppression take the dose... About storage and disposal of this medication down the toilet treat rheumatoid arthritis and juvenile rheumatoid arthritis ulcerative., SP is 10.4 hours while in slow acetylators, it is considered by some to be first. ( or are metabolized to ) mesalamine in clinical practice deaths due to ingestion large. Body weight in each 24-hour period, divided into 4 doses no documented reports of deaths due to low levels. Drugs that are substrates for this transporter, such as drowsiness, convulsions, etc., may exhibit increase. Most common adverse reactions and of the need for careful medical supervision rats, (. A doctor or pharmacist to explain any part you do not take a double dose make. As sulfasalazine, 500 mg to 3 grams daily in two to four doses, you should bring list. Body which causes tissue damage, inflammation, and procedures ; then consult the database 5,000+... Effects, the sulfasalazine drug class should be stopped for 5 to 7 days then. Prolonged plasma half-life are not always predictive of human response, this drug should stopped! Of male fertility was observed in male rats East-West Highway, Suite 900, Bethesda Maryland... Age of 4 years with ulcerative colitis and to wear protective clothing, sunglasses, and diarrhea to make for!

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